📥 Inbound Notifications 669

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2026-04-05 06:49:46 urn:uuid:450ea2bb-1679-4c04-8adf-3bfe9b87f084 https://datalake.inria.fr https://inria.hal.science ["Offer","coar-notify:ReviewAction"]
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            "In YOC, the tool presented here, we rely on OverlapChainer (OC) for the chaining phase.",
            "YOC uses YASS, a highly sensitive local alignment software in phase one, and OverlapChainer, a chaining algorithm allowing for proportional overlaps between the anchors in phase two.",
            "We also introduced the first algorithm to solve this problem (which takes quadratic time as a function of the number of fragments) and implemented it in a tool called OverlapChainer (OC).",
            "Phase (1): YOC enhances the similarity detection phase by computing local alignments with YASS     ; and phase (2): it chains the local alignments using a recent chaining algorithm, OverlapChainer (OC)     ."
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2026-04-05 06:49:46 urn:uuid:3e4509e1-961b-4e15-a9fa-2042940e440c https://datalake.inria.fr https://inria.hal.science ["Offer","coar-notify:ReviewAction"]
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            "ProgressiveMAUVE produced quite good results, with 85% of the orthologous genes completely and correctly included in the backbone segments.",
            "MAUVE and ProgressiveMAUVE had the highest coverage values, close to 100%, regardless of the genome divergence levels.",
            "2) MAUVE and ProgressiveMAUVE yielded the longest alignments (on average 2.9 million positions for Lactobacillus and 6.0 million positions for Bacillus cereus, i.e. 100% coverage) including only a few long segments (respectively 2/1 on average with MAUVE/ProgressiveMAUVE in Lactobacillus, and 3/33 with MAUVE/ProgressiveMAUVE in Bacillus cereus).",
            "MGA, MAUVE, and ProgressiveMAUVE include additional parameters linked to the four phases strategy, for instance the lengths of the matches that are used in the first and the third phases (P1 and P3) are critical.",
            "Therefore MGA and MAUVE/ ProgressiveMAUVE are difficult to incorporate in large-scale automated studies.",
            "We observed that MGA, MAUVE and ProgressiveMAUVE, which all include the third and fourth phases of the anchor-based strategy, yielded alignments with high genome coverage, but of which a considerable proportion was detected as being unreliable.",
            "This may be due to the fact that ProgressiveMAUVE was designed and tuned for the alignment of multiple genomes.",
            "But more surprisingly, MAUVE and ProgressiveMAUVE alignments included high rates of gap positions, which reached 40% of the alignment, even for moderate levels of divergence (divergence > 0.2, according to MUMi values).",
            "Moreover, the parameters of MAUVE/ProgressiveMAUVE need to be adjusted to the level of nucleotide divergence among the genomes to be aligned, even at the intra-species level.",
            "YOC coverages were between those of MAUVE/ProgressiveMAUVE and MUMmer.",
            "On average, of all B. cereus pairs, 20% of ProgressiveMAUVE's alignment was filtered out.",
            "positions = 22.45% for Bacillus cereus) and ProgressiveMAUVE Values correspond to the average, the minimum and the maximum alignment coverages before and after applying the GRA-FIL filtering procedure, as well as the average, the minimum and the maximum for the GRA-FIL criterion (i.e., the percentage of likely erroneous alignment positions).",
            "It is also interesting to note an unexpected result: ProgressiveMAUVE does not systematically produce better results than MAUVE.",
            "Moreover, after filtration, the alignment lengths obtained with MAUVE and ProgressiveMAUVE were equal to those produced with YOC.",
            "This conclusion was corroborated on Dataset 3, which revealed MAUVE's and ProgressiveMAUVE's tendency to include an increasing number of mismatches and gaps for higher divergence levels, compared to YOC, which offers a good compromise between coverage and percentage of identities.",
            "Finally, its alignments comprised fewer segments than those of MGA, MAUVE, or ProgressiveMAUVE.",
            "This phenomenon is clearly illustrated in Figure 5, which shows the backbones of MAUVE, ProgressiveMAUVE, and YOC.",
            "with default parameters except for'-weight = 5000' and'-output-alignment' for XMFA file output ProgressiveMAUVE 2.3.1 with default parameters except for'-output-alignment' option for XMFA file output YOC 1.0 with default parameters : for 'YASS' (parameter 'E-value threshold': 10) and for Overlap Chainer (parameter 'overlap ratio' : 10%).",
            "To facilitate the comparison of the results, we used the XMFA alignment format produced by MAUVE and ProgressiveMAUVE aligners (for description, see http://darlinglab.org/mauve/user- guide/files.html)",
            "YOC does less work but achieves similar levels of coverage and identity to a sophisticated aligner like ProgressiveMAUVE.",
            "To summarize, based on the GRA-FIL quality criterion, the results in Tables 3 and 4 suggest that MAUVE and ProgressiveMAUVE extend their alignments by including regions of questionable similarity, while in only two phases, YOC produces the most reliable alignments of all.",
            "To summarize, unlike classical WGA tools designed for similar genomes (like MGA, MUMmer (NUCmer), MAUVE, LAGAN, ProgressiveMAUVE), YOC focuses on almost collinear, highly divergent pairwise WGA, and simplifies the anchor based strategy by implementing only the first two phases (see Figure 1), without any refinement steps like realignment, filtering, or recursive alignment.",
            "The use of spaced seeds and local alignments (mostly BLAST-like) is not entirely new in the WGA field: e.g., MAUVE and ProgressiveMAUVE use inexact but ungapped matches as anchors, GRIMM-Synteny [10], PipMaker [12], LAGAN [14] and LASTZ [28], which use BLASTlike local alignments, while MAGIC [8] can be run with YASS local alignments.",
            "Strategies for dealing with overlaps include accepting fixed, maximum length overlaps and trimming them (like in MAUVE and ProgressiveMAUVE) and segment match refinement (like in [36,37]).",
            "Based on the preliminary results listed in Table 2, we decided to compare five genome aligners, MGA, MUMmer (NUCmer), MAUVE, ProgressiveMAUVE and YOC, using the intra-species pairs of genomes from Dataset 2. Given that MUMmer (NUCmer) uses exact matches (unique or not) and that it does not include the 'last chance alignment phase' , the length of its alignment can serve as a lower bound of the number of alignable positions.",
            "For example, the number of aligned segments, a measure of the alignment fragmentation, is not directly comparable between MAUVE, ProgressiveMAUVE and the other genome aligners: for MUMmer (NUCmer), MAUVE and ProgressiveMAUVE it represents the number of Locally Collinear Blocks (LCBs) in the alignments, i.e. roughly the number of inversions and translocations; for MGA and YOC, it is the number of segments that are interrupted by insertions/deletions and local inversions (for YOC only).",
            "Lactococcus lactis case study (Dataset 4) Table 5 and Figure 5 show the results of a detailed analysis of three genome alignments produced by MAUVE, ProgressiveMAUVE and YOC on two Lactococcus lactis genomes, which were post-processed by filtering the low quality alignment regions (with more than 20 consecutive gaps) and the weakly conserved regions (with less than 76% of identity).",
            "Moreover, according to its coverage of alignments and the number of identities, YOC directly outputs alignments similar to those obtained with MAUVE and ProgressiveMAUVE after filtration with GRAPe.",
            "MAUVE also forces the alignment of unrelated sequences and its authors are aware of the problem, which is discussed in [20], and was claimed to be solved in ProgressiveMAUVE [6] (which includes a post-alignment filtration step).",
            "Despite many efforts in this field and the availability of numerous genome aligners, some of which were specially designed for bacterial genomes (e.g., MGA [4], MAUVE [5], ProgressiveMAUVE [6], MUGSY [7], MAGIC [8]) and others that target more complex genomes (e.g., MUMmer [9], GRIMM-Synteny [10], CHAINNET [11], PipMaker [12]), none is yet completely satisfactory.",
            "Even though in terms of the total number of orthologous positions included in the alignment backbone (this means taking into account orthologs that overlap both backbone and variable segments) ProgressiveMAUVE obtained better scores than YOC (97.4% compared to 95.2%), the corresponding ProgressiveMAUVE backbone segments tended to hatch the orthologous genes and were less relevant from a biological viewpoint.",
            "Figure 3b shows that increasing the level of divergence mainly affected the alignment mean percentage of identity for all four tools (which decreases linearly), but had more drastic effects on MAUVE and ProgressiveMAUVE alignments than on YOC and MUMmer alignments.",
            "For example, the number of aligned segments, a measure of the alignment fragmentation, is not directly comparable between MAUVE, ProgressiveMAUVE and the other genome aligners: for MUMmer (NUCmer), MAUVE and ProgressiveMAUVE it represents the number of Locally Collinear Blocks (LCBs) in the alignments, i.e. roughly the number of inversions and translocations; for MGA and YOC, it is the number of segments that are interrupted by insertions/deletions and local inversions (for YOC only).",
            "Six genome aligners, all based on the anchoring strategy, were compared on the previously described genome datasets; two state-of-the-art aligners, MGA [4] and LAGAN [14], clearly target collinear genomes, three others, MAUVE [5], ProgressiveMAUVE [6] and MUMmer [9] are able to align either rearranged or collinear genomes whatever their type of rearrangements, while our new method, YOC, aligns pairs of collinear genomes (possibly including locally inversed segments but no translocated segments).",
            "Indeed, after filtration, their mean alignment lengths dropped to 2.4 million positions for Lactobacillus (mean coverage: 91%), and to 4.4 million positions (mean coverage 83% with MAUVE) or 4.2 million positions (mean coverage 81% with ProgressiveMAUVE) for Bacillus cereus.",
            "2) MAUVE and ProgressiveMAUVE yielded the longest alignments (on average 2.9 million positions for Lactobacillus and 6.0 million positions for Bacillus cereus, i.e. 100% coverage) including only a few long segments (respectively 2/1 on average with MAUVE/ProgressiveMAUVE in Lactobacillus, and 3/33 with MAUVE/ProgressiveMAUVE in Bacillus cereus).",
            "Even though in terms of the total number of orthologous positions included in the alignment backbone (this means taking into account orthologs that overlap both backbone and variable segments) ProgressiveMAUVE obtained better scores than YOC (97.4% compared to 95.2%), the corresponding ProgressiveMAUVE backbone segments tended to hatch the orthologous genes and were less relevant from a biological viewpoint.",
            "2) MAUVE and ProgressiveMAUVE yielded the longest alignments (on average 2.9 million positions for Lactobacillus and 6.0 million positions for Bacillus cereus, i.e. 100% coverage) including only a few long segments (respectively 2/1 on average with MAUVE/ProgressiveMAUVE in Lactobacillus, and 3/33 with MAUVE/ProgressiveMAUVE in Bacillus cereus).",
            "The measures of the reliability of the backbone alignments obtained using the basic indicators (number of segments, mean coverage and percentage of identity) differed considerably between the three aligners: MAUVE tended to produce a highly fragmented (3121 segments) and low-coverage (64% mean coverage) but a highly conserved backbone (89% identity), the results of ProgressiveMAUVE were intermediate, with a less fragmented backbone (759 segments), medium coverage (77%) and good percentage of identity (86%).",
            "These four phases can be clearly identified in aligners targeting bacterial genomes, like MGA [4], which uses exact matches and a collinear chaining algorithm, LAGAN [14] (which is meant to deal with more divergent but still collinear sequences), which uses local alignments, collinear chaining and a dynamic programming alignment stage in the fourth phase, MAUVE [5] and ProgressiveMAUVE [6], which work with nearly exact matches and use a heuristic that produces a non-collinear chain."
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2026-04-05 06:49:41 urn:uuid:5491f3f1-9a58-4fc6-855a-0ad3f675ed00 https://datalake.inria.fr https://inria.hal.science ["Offer","coar-notify:ReviewAction"]
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2026-04-05 06:49:36 urn:uuid:b2af5334-a284-489e-a442-1fc436474aae https://datalake.inria.fr https://inria.hal.science ["Offer","coar-notify:ReviewAction"]
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            "We used ChromstaR (Taudt et al., 2016) to analyze the spatial pattern of statistically significant enrichment in each histone modification associated with different functional genomic elements in M. incognita.",
            "The mean enrichment profiles were calculated by ChromstaR, based on the log(expected/observed) enrichment from 2 kb upstream to 2 kb downstream from the protein-coding genes, considering only the top and bottom 10% of genes ranked according to expression level associated with the five histone modifications.",
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            "The DC01 and the DP450 Hill'48 behaviors are used for experimental to numerical comparisons in Sections 5 and 6.",
            "Pour l'acier DC01, les pr\u00e9-d\u00e9formations sont r\u00e9alis\u00e9es deux fois pour chaque niveau, les d\u00e9formations \u00e0 rupture obtenues se r\u00e9v\u00e8lent r\u00e9p\u00e9tables.",
            "DP450 Hill'48 and DC01 models, see Table 3.1.",
            "\ud835\udc4e[-] \ud835\udc4f[-] \ud835\udc50[-] DC01 1,33 1,35 0,079 \u03b5 \ud835\udc46\ud835\udc3b [-] \u03b5 \ud835\udc48\ud835\udc47 [-] \u03b5 \ud835\udc43 \ud835\udc46\ud835\udc47 [-] DC01 1,55 1,35 0,68  Les trajets de chargement r\u00e9alis\u00e9s sur l'acier DC01 sont repr\u00e9sent\u00e9s en rouge.",
            "In the case of the DC01 steel, three sequential tests are presented and compared to one monotonic test.",
            "Dans le cas de l'acier DC01, la corr\u00e9lation d'image r\u00e9alis\u00e9e en dynamique donne des r\u00e9sultats comparables en termes d'\u00e9volution de la d\u00e9formation le long d'une ligne radiale, par rapport \u00e0 ce qui peut \u00eatre obtenu en quasi-statique.",
            "Le mod\u00e8le de rupture du DC01 en 1 mm d'\u00e9paisseur est identifi\u00e9 \u00e0 partir des essais de \ud835\udc4e[-] \ud835\udc4f[-] \ud835\udc50[-] DP450 1,45 1,35 0,038 \u03b5 \ud835\udc46\ud835\udc3b [-] \u03b5 \ud835\udc48\ud835\udc47 [-] \u03b5 \ud835\udc43 \ud835\udc46\ud835\udc47 [-] DP450 1,45 1,35 0,81  cisaillement optimis\u00e9s, traction sur une \u00e9prouvette Central Hole (CH) et essai de traction plane (DH-PST).",
            "Les essais r\u00e9alis\u00e9s sur le DC01 confirment la m\u00eame tendance que celle observ\u00e9e sur le DP450.",
            "2.11 Param\u00e8tres mat\u00e9riaux pour le DC01. . . . . . . . . . . . . . . . . . . . . . .",
            "This is the case for the two steels DC01 and DP450.",
            "Les r\u00e9sultats des essais sur l'acier DC01 avec les r\u00e9p\u00e9tabilit\u00e9s issus de la machine de traction sont pr\u00e9sent\u00e9s en Annexes.",
            "La campagne exp\u00e9rimentale sur l'acier DC01 a permis de r\u00e9aliser des essais de torsion \u00e0 diff\u00e9rentes vitesses de d\u00e9formation, 10 -3 s -1 , 10 -1 s -1 et 10 3 s -1 ainsi que la mesure de l'\u00e9volution de la temp\u00e9rature pour l'essai le plus rapide.",
            "33 1.4 Caract\u00e9risation de l'acier doux DC01 . . . . . . . . . . . . . . . . . .",
            "The same holds true in the case of the DC01 steel and the two first sequences in the case of the AA6014-T4 aluminum alloy.",
            "Notre choix s'est port\u00e9 sur l'acier doux DC01 lamin\u00e9 \u00e0 froid en t\u00f4le de",
            "Table 2.11 -Param\u00e8tres mat\u00e9riaux pour le DC01.",
            "Le r\u00e9sultat d'un essai DH-PST sur l'acier DC01 est pr\u00e9sent\u00e9 figure 1.11.",
            "The experiments conducted on DP450 steel, DC01 steel, and AA6014 aluminum alloy validate the numerical findings regarding the strain field.",
            "La figure 4  pour l'acier DP450 et l'acier DC01.",
            "Les courbes contraintes vs d\u00e9formations du DC01 obtenues par ces 2 dispositifs co\u00efncident.",
            "chimique et propri\u00e9t\u00e9s m\u00e9caniques de l'acier DC01",
            "Param\u00e8tres d'\u00e9crouissage identifi\u00e9s pour l'acier DC01",
            "1.4 Param\u00e8tres d'\u00e9crouissage identifi\u00e9s pour l'acier DC01 . . . . . . . . . . . . . . 1.5 Coefficients de Lankford et contraintes limites \u00e9lastique identifi\u00e9s pour l'acier DC01 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.6 Param\u00e8tres du mod\u00e8le Hill'48 non associ\u00e9 identifi\u00e9s pour l'acier DC01 . . . . .",
            "4.6 R\u00e9sultats pour les essais de PST -SH sur l'acier DC01. . . . . . . . . . . . . 4.7 R\u00e9sultats pour les essais de EQBT -PST sur l'acier DP450. . . . . . . . . . .",
            "4.8 R\u00e9sultats pour les essais de EQBT -PST sur l'acier DC01. . . . . . . . . . .",
            "La caract\u00e9risation du mod\u00e8le est r\u00e9alis\u00e9e sur un acier DC01.",
            "Numerical results of the monotonic shear simulation of the DC01 is plotted using orange empty circles. . . . . . . . . . . . . . . . . . . . . . . . . . . .",
            "Table 4.4 -R\u00e9sultats pour les essais de SH -PST sur l'acier DC01.",
            "1.2 Composition chimique et propri\u00e9t\u00e9s m\u00e9caniques de l'acier DC01 . . . . . . . .",
            "The same results are presented in Fig. 3.23 in the case of the DC01 steel and the AA6014-T4 aluminum alloy.",
            "1.6 Param\u00e8tres du mod\u00e8le Hill'48 non associ\u00e9 identifi\u00e9s pour l'acier DC01 . . . . .",
            "4.2 Param\u00e8tres du mod\u00e8le de rupture de Hosford-Coulomb pour un acier DC01. .",
            "Pour caract\u00e9riser l'influence de la temp\u00e9rature sur le comportement du DC01 en quasistatique, une campagne exp\u00e9rimentale a \u00e9t\u00e9 r\u00e9alis\u00e9e avec des essais de traction \u00e0 trois niveaux de temp\u00e9rature : 120 \u00b0C, 240 \u00b0C et 350 \u00b0C, cette derni\u00e8re temp\u00e9rature \u00e9tant celle atteinte en torsion dynamique.",
            "Par exemple, Farahnak et al. [129] ont \u00e9tudi\u00e9 le comportement de l'acier DC01 en compression, traction et la sensibilit\u00e9 \u00e0 la vitesse.",
            "Des exp\u00e9riences sont r\u00e9alis\u00e9es sur trois mat\u00e9riaux, l'acier DP450, l'acier DC01 et l'aluminium AA6014-T4, avec jusqu'\u00e0 cinq s\u00e9quences de chargement et d'usinage.",
            "\ud835\udc4e[-] \ud835\udc4f[-] \ud835\udc50[-] DC01 1,33 1,35 0,079 \u03b5 \ud835\udc46\ud835\udc3b [-] \u03b5 \ud835\udc48\ud835\udc47 [-] \u03b5 \ud835\udc43 \ud835\udc46\ud835\udc47 [-] DC01 1,55 1,35 0,68  Les trajets de chargement r\u00e9alis\u00e9s sur l'acier DC01 sont repr\u00e9sent\u00e9s en rouge.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.21 -\u00c9volution de l'accumulation de l'endommagement pour le trajet PST -SH (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.22 -\u00c9volution de l'accumulation de l'endommagement pour le trajet EQBT -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "La combinaison SH -PST est pr\u00e9sent\u00e9e figure 4.15 pour le DP450 et figure 4.20 pour le DC01, le trajet PST -SH figure 4.16 pour le DP450 et figure 4.21 pour le DC01 , le trajet EQBT -PST figure 4.17 pour le DP450 et figure 4.22, le trajet UT -EQBT figure 4.18 pour le DP450 et le trajet UT -PST figure 4.19 pour le DP450.",
            "Pour l'acier DP450, il y a trois r\u00e9p\u00e9titions de la combinaison et deux pour le l'acier DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.15 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DP450.",
            "3.23 Shear stress versus strain curves of sequential machining and simple shear test of DC01 steel and AA6014-T4 aluminum alloy.",
            "Three more sets of parameters are based on the literature, corresponding to DP450 steel, DC01 steel, and AA2024-T3 aluminum alloy.",
            "Cette partie est consacr\u00e9e \u00e0 la mod\u00e9lisation et caract\u00e9risation du comportement m\u00e9canique du DC01, un acier doux pr\u00e9sentant une ductilit\u00e9 importante.",
            "Landi et al. [73] ont trouv\u00e9 une valeur de m = 0,7, T melt = 1792 K et C = 0,02 pour un acier DC01.",
            "4.12 Param\u00e8tres identifi\u00e9s pour la m\u00e9thode m&m et la m\u00e9thode Cortese et al. [155] pour l'acier DC01. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .",
            "La pr\u00e9-d\u00e9formation correspond \u00e0 37 % de la d\u00e9formation \u00e0 rupture en PST pour le DP450 et 52 % pour le DC01.",
            "A final comparison of the experimental stress-strain curves obtained from sequential shear of DP450 and DC01 with published results reveals maximum errors of 4 % in stress, for effective strains up to 0,8.",
            "The experimental and the numerical results of monotonic tests are presented in the case of the DP450 and DC01 steels, showing a good agreement for these behavior models leading to an error in force lower than 4 %, similar to previously published results, see [148], [49], [48] for examples.",
            "4.14 R\u00e9sum\u00e9 des d\u00e9formations et indicateur d'endommagement pour les combinaisons de trajets r\u00e9alis\u00e9s sur le DC01. . . . . . . . . . . . . . . . . . . . . . . .",
            "Table 4.14 -R\u00e9sum\u00e9 des d\u00e9formations et indicateur d'endommagement pour les combinaisons de trajets r\u00e9alis\u00e9s sur le DC01.",
            "Experiments are performed on three engineering sheet materials : a 0,8 mm thick DP450 dual phase steel, a 1,0 mm thick DC01 deep drawing steel and a 1,1 mm thick AA6014-T4 aluminum alloy.",
            "Lors d'un essai quasi-statique, une zone conique trop grande conduit \u00e0 du flambement pour certains mat\u00e9riaux comme l'acier DC01.",
            "Their sets of experiments used for the hybrid experimental-numerical identification method comprised in-plane torsion tests (DC01) and bulge tests (DP450).",
            "Stress versus strain curve of the monotonic (black solid line) and the in-plane torsion experiments (dashed black line) of the DC01 steel. . . . . . . . . . . . . . . . . . . . . . . . . . .",
            "PST SH \ud835\udf00 \ud835\udc52\ud835\udc53\ud835\udc53 [-] \ud835\udf00 \ud835\udc52\ud835\udc53\ud835\udc53 [-] W120 1 0,25 1,00 W120 2 0,24 1,05 Table 4.6 -R\u00e9sultats pour les essais de PST -SH sur l'acier DC01.",
            "Ces r\u00e9sultats n'ont rien de g\u00e9n\u00e9ral, puisque d\u00e9pendant des valeurs initiales consid\u00e9r\u00e9es, en l'occurrence celles obtenues pour le DC01 en traction.",
            "For detailed description of the test, readers should refer to the article by Grolleau et al. [9] presenting the in-plane torsion of DC01 steel.",
            "Additionally, a comparison with edge-free in-plane torsion testing shows that the sequential shear test yields the same results for DC01 steel.",
            "Le mod\u00e8le de mat\u00e9riau choisi, isotrope de type Levy von Mises suit un \u00e9crouissage de type loi puissance similaire \u00e0 celui de l'acier DC01.",
            "Ce chapitre se conclut avec la comparaison d'un essai de torsion et des essais de cisaillement avec r\u00e9-usinage r\u00e9alis\u00e9s sur des aciers DC01.",
            "4.3 R\u00e9sultats pour les essais de SH -PST sur l'acier DP450. . . . . . . . . . . . . 4.4 R\u00e9sultats pour les essais de SH -PST sur l'acier DC01. . . . . . . . . . . . .",
            "0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 0 0.5 1 1.5 2 2.5 3 3.5 Strain [-] Shear ratio [-] Von Mises work equivalent strain Effective strain DC01 Figure 1.5 -Comparaison des mesures de d\u00e9formation \u00e9quivalente conjugu\u00e9e au travail de von Mises (ligne rouge) et de d\u00e9formation effective (ligne bleue) pour un cisaillement simple en fonction du cisaillement de l'ing\u00e9nieur.",
            "Rolling Direction Les tableaux 4.5 et 4.6 indiquent les niveaux de d\u00e9formations atteints lors de la combinaison PST -SH pour le DP450 et le DC01, la pr\u00e9-d\u00e9formation correspond \u00e0 21 % de la d\u00e9formation \u00e0 rupture en cisaillement pour le DP450 et 15 % pour le DC01.",
            "\ud835\udc4e[-] \ud835\udc4f[-] \ud835\udc50[-] DC01 1,33 1,35 0,079 \u03b5 \ud835\udc46\ud835\udc3b [-] \u03b5 \ud835\udc48\ud835\udc47 [-] \u03b5 \ud835\udc43 \ud835\udc46\ud835\udc47 [-] DC01 1,55 1,35 0,68  Les trajets de chargement r\u00e9alis\u00e9s sur l'acier DC01 sont repr\u00e9sent\u00e9s en rouge.",
            "EQBT PST \ud835\udf00 \ud835\udc52\ud835\udc53\ud835\udc53 [-] \ud835\udf00 \ud835\udc52\ud835\udc53\ud835\udc53 [-] W200 1 0,30 0,52 W200 2 0,29 0,49 W200 3 0,30 0,53 Table 4.8 -R\u00e9sultats pour les essais de EQBT -PST sur l'acier DC01.",
            "La combinaison SH -PST est pr\u00e9sent\u00e9e figure 4.15 pour le DP450 et figure 4.20 pour le DC01, le trajet PST -SH figure 4.16 pour le DP450 et figure 4.21 pour le DC01 , le trajet EQBT -PST figure 4.17 pour le DP450 et figure 4.22, le trajet UT -EQBT figure 4.18 pour le DP450 et le trajet UT -PST figure 4.19 pour le DP450.",
            "3.21 Evolution of the force as a function of the effective strain during sequential shear (solid green line) and monotonic (solid black line) shear test of the DC01 steel, and sequential shear of AA6014-T4 aluminum alloy (solid red line).",
            "Dans ce chapitre, trois combinaisons de trajets de chargements sont pr\u00e9sent\u00e9es et r\u00e9alis\u00e9es sur deux aciers, un acier dual phase DP450 de 0,8 mm d'\u00e9paisseur et un DC01 de 1 mm d'\u00e9paisseur (ce DC01 est diff\u00e9rent de celui pr\u00e9sent\u00e9 dans le chapitre 1 et 2) : cisaillement -traction \u00e0 d\u00e9formation plane (SH -PST), traction \u00e0 d\u00e9formation plane -cisaillement (PST -SH), \u00e9quibiaxiale -traction \u00e0 d\u00e9formation plane (EQBT -PST).",
            "Le tableau 4.13 r\u00e9sume les valeurs de d\u00e9formations et les indicateurs d'endommagement pour tous les trajets r\u00e9alis\u00e9s sur l'acier DP450 et le tableau 4.14 pour l'acier DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.21 -\u00c9volution de l'accumulation de l'endommagement pour le trajet PST -SH (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "Le niveau de d\u00e9formation choisi pour le calcul des ratio des contraintes est pr\u00e9sent\u00e9 figure 1 Table 1.6 -Param\u00e8tres du mod\u00e8le Hill'48 non associ\u00e9 identifi\u00e9s pour l'acier DC01 (a) (b) (c) (d) TORSION PLANE Contents 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .",
            "1.4 Param\u00e8tres d'\u00e9crouissage identifi\u00e9s pour l'acier DC01 . . . . . . . . . . . . . . 1.5 Coefficients de Lankford et contraintes limites \u00e9lastique identifi\u00e9s pour l'acier DC01 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.6 Param\u00e8tres du mod\u00e8le Hill'48 non associ\u00e9 identifi\u00e9s pour l'acier DC01 . . . . .",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.22 -\u00c9volution de l'accumulation de l'endommagement pour le trajet EQBT -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "3.24 Shear stress versus effective strain curves of sequential shear machining tests (solid lines) and simple shear numerical simulation of a single element (empty circles) for DC01 and DP450 steels. . . . . . . . . . . . . . . . . . . . . . . .",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.15 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DP450.",
            "Dans ce chapitre, trois combinaisons de trajets de chargements sont pr\u00e9sent\u00e9es et r\u00e9alis\u00e9es sur deux aciers, un acier dual phase DP450 de 0,8 mm d'\u00e9paisseur et un DC01 de 1 mm d'\u00e9paisseur (ce DC01 est diff\u00e9rent de celui pr\u00e9sent\u00e9 dans le chapitre 1 et 2) : cisaillement -traction \u00e0 d\u00e9formation plane (SH -PST), traction \u00e0 d\u00e9formation plane -cisaillement (PST -SH), \u00e9quibiaxiale -traction \u00e0 d\u00e9formation plane (EQBT -PST).",
            "These behavior law parameters have been identified using a hybrid experimental-numerical method from uniaxial tension experiments of dog-bone and notched specimens, see [66] (DP450 steel and AA2024-T3 aluminum alloy), and [9] (DC01 steel) for details.",
            "Rolling Direction Les tableaux 4.5 et 4.6 indiquent les niveaux de d\u00e9formations atteints lors de la combinaison PST -SH pour le DP450 et le DC01, la pr\u00e9-d\u00e9formation correspond \u00e0 21 % de la d\u00e9formation \u00e0 rupture en cisaillement pour le DP450 et 15 % pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.21 -\u00c9volution de l'accumulation de l'endommagement pour le trajet PST -SH (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.22 -\u00c9volution de l'accumulation de l'endommagement pour le trajet EQBT -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "Ce trajet de chargement est \u00e0 param\u00e8tre de Lode non constant, passant de \u03b8 = -1 \u00e0 \u03b8 = 0, et une triaxialit\u00e9 passant de \ud835\udf02 = 2/3 \u00e0 \ud835\udf02 = 1/ \u221a 3. Les tableaux 4.7 et 4.8 indiquent les niveaux de d\u00e9formations atteints lors de la combinaison EQBT -PST pour le DP450 et le DC01.",
            "Table 3.1 -Behavior law parameters \ud835\udf0e 0 [MPa] Q [MPa] b K [MPa] n \ud835\udf16 0 \ud835\udefc Voce 1 162 234 40 ---0 Voce 2 162 234 10 ---0 Swift ---555 0,2 0,001 1 Linear hardening 540 0. 0 1000 1 0,0 0,5 DP450 [66] 308 273 17,6 838 0.2 0,004 0,907 AA2024-T3 [66] 364 240 10,8 798 0,2 0,018 0,368 DC01 [9] 290 86 8,8 617 0,2 0,0007 0,865 Hill'48 NAFR model \ud835\udc43 22 \ud835\udc43 33 \ud835\udc43 12 \ud835\udc3a 22 \ud835\udc3a 33 \ud835\udc3a 12 DP450 [66]",
            "When compared to the sequential shear and monotonic shear test results, a clear agreement is obtained up to an effective strain value about 0,8. Figure 3.24 shows the evolution of the shear stress as a function of the effective strain for sequential shear tests conducted on DP450 and DC01 steels.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.15 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DP450.",
            "En effet, la diff\u00e9rence pour une d\u00e9formation de 1 entre 4 et 8 \u00e9l\u00e9ments est de 0,5 % et entre 8 et 14 \u00e9l\u00e9ments de 0,1 %.En revanche, l'\u00e9tude de l'\u00e9volution de la d\u00e9formation le long d'un cercle de rayon 23 mm montre une diff\u00e9rence sur les valeurs maximales de 3,8 % entre 4 et 8 \u00e9l\u00e9ments dans le cas d'un mod\u00e8le anisotrope (Hill'48 NAFR de l'acier DC01), de 1,29 % entre 8 et 14 \u00e9l\u00e9ments, et de 5,2 % entre 4 et 14 \u00e9l\u00e9ments.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.21 -\u00c9volution de l'accumulation de l'endommagement pour le trajet PST -SH (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.22 -\u00c9volution de l'accumulation de l'endommagement pour le trajet EQBT -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 cortese (c) Chapitre 4 -Trajets de chargement et rupture sous chargements non proportionnels 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.20 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 cortese (c) Chapitre 4 -Trajets de chargement et rupture sous chargements non proportionnels 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.20 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 cortese (c) Chapitre 4 -Trajets de chargement et rupture sous chargements non proportionnels 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.20 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01.",
            "0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 Damage total Damage Load 1 Damage = 1 Damage [-] DP450 cortese (c) Chapitre 4 -Trajets de chargement et rupture sous chargements non proportionnels 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 linear (a) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 m&m (b) 0 0.2 0.4 0.6 0.8 1 1.2 1 2 3 4 5 6 7 Damage total Damage Load 1 Damage = 1 Damage [-] DC01 cortese (c) Figure 4.20 -\u00c9volution de l'accumulation de l'endommagement pour le trajet SH -PST (a) loi lin\u00e9aire, (b) loi m&m, (c) loi Cortese pour le DC01."
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            "SBRT involves directing highly focused external beam radiation therapy to target a well-defined and demarcated volume of tissue.",
            "SBRT precisely delivers a high dose to an extracranial well-limited tumour, in a single or a few fractions (fewer than six).",
            "SBRT has emerged as standard therapy for early-stage lung cancer, for localized prostate cancer and primary pancreatic, liver, kidney and breast cancer, and for limited metastatic disease.",
            "SBRT for cardiac arrhythmias is also referred to as stereotactic arrhythmia radioablation (STAR).",
            "SBRT appears to be extremely appropriate for the delivery of high energy to a specific part of the heart.",
            "In lung SBRT, the median dose to the left ventricle was 0.2 Gy and 0.8 Gy to the left anterior descending artery.",
            "Although SBRT is designed to minimize toxicity to adjacent structures, respiratory and cardiac motion increase the risk of off-target delivery.",
            "The extension of SBRT to cardiac tissue came with the recognition that respiratory gating can effectively reduce the treated volume of the heart [16].",
            "The radiobiology of SBRT remains to be completely characterized.",
            "The key requirement for SBRT is therefore a high level of accuracy at each step of the treatment process [15].",
            "The immediate attraction of non-invasive SBRT for VT ablation is its suitability for patients in whom standard VT ablation has failed or is deemed not feasible, particularly sicker patients and those with epicardial substrate with previous cardiac surgery or VT substrates that are not accessible to current methodologies, such as deep intraseptal or intramural substrate.",
            "Another potential technology suitable for SBRT is proton or carbon beam therapy, which is used less frequently than photon therapy, as it requires large and costly accelerators.",
            "This risk profile, although acceptable when SBRT is used as palliation, might be of concern for patients who have an anticipated longer survival.",
            "Lloyd et al. [7] reported microscopic analysis of the SBRT-treated regions in the hearts of three patients who underwent cardiac transplant.",
            "The advantages are that delineation of the volume to treat by SBRT can be performed on a dedicated CT scan, and that an additional CT scan or chest X-ray performed on-line in the radioablation unit may be used to optimize the tracking at the cost of additional irradiation.",
            "Early feasibility studies of single-fraction stereotactic body radiotherapy (SBRT) have demonstrated encouraging results [5][6][7][8][9][10], but rigorous evaluation and follow-up are required because of potential delayed complications [6,8].",
            "It is of particular importance that such a platform proves to be compatible with SBRT software, to define with accuracy the internal target volume after merging these data.",
            "While we await technological improvements (cardiac on top of respiratory gating) in the SBRT system, a platform (Fig. 2) integrating all imaging and electrophysiological information to refine delineation of the target volumes is warranted, to optimize the workflow and accuracy of SBRT delivery; as a byproduct this will limit the planning target volume, reducing potential side effects.",
            "However, even if only a limited number of complications have been reported so far after SBRT [10], there is a need for a national registry including all patients receiving this treatment, to evaluate longterm efficacy and safety, and further determine the place of STAR in VT management.",
            "This defines the gross target volume, which is manually delineated on the planning software coupled to the SBRT system, increasing the risk of approximation.",
            "To achieve the required dose calculation accuracy, the planning system should be specifically commissioned for SBRT, with a dedicated beam model, and the algorithm should account for tissue heterogeneities.",
            "At present, medical physicists and radiation oncologists have to delineate the target identified by the electrophysiologist manually into the SBRT system, and undertake treatment planning to eradicate it and avoid collateral damage.",
            "LINACs equipped with image guidance, a high-resolution multileaf collimator and improved mechanical accuracy are recommended for best practice of SBRT [14], as well as a dedicated linear accelerator (LINAC), such as the Cyberknife\u00ae (Accuracy Incorporated, Sunnyvale, CA, USA).",
            "However, the development of linear accelerators (LINACs), advances in imaging and new means of treatment, such as gating, tracking and intensity modulation, have enabled the application of stereotactic radiation to extracranial organs, and it is now referred to as SBRT [13] (or stereotactic ablative radiotherapy [SABR] when the target is outside the central nervous system).",
            "While we await technological improvements (cardiac on top of respiratory gating) in the SBRT system, a platform (Fig. 2) integrating all imaging and electrophysiological information to refine delineation of the target volumes is warranted, to optimize the workflow and accuracy of SBRT delivery; as a byproduct this will limit the planning target volume, reducing potential side effects."
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            "The NMP MOOC was included in the analysis for identifying what indicators to be used in students' dashboards, while the analysis of the Coursera dashboards and Moodle plugins were selected for the indicators to be used in teachers' dashboards.",
            "In this phase, we conducted an exhaustive analysis of the indicators used in NMP MOOC, in the Coursera dashboards (platform in which NMP MOOC was evaluated), and in existing Moodle plugins designed for supporting teachers in students' monitoring (such as SmartKlass, Dropout Detective dashboard, Plugin Analytics, GISMO, Intelliboard moodle dashboard).",
            "This paper presents the design process followed for transforming a previous plugin designed for supporting SRL in MOOCs called NoteMyProgress MOOC (NMP MOOC) [12] into a Plugin for Moodle aimed at supporting SRL in BL courses.",
            "In Activity 1, and as a form of elicit visualization opportunities and explore different solutions, participants were provided with a document with a list of numbered visualizations used in Coursera, Moodle and NMP 1.0 that were related with the needs extracted from the Informed Exploration phase.",
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